MHH DISSERTATION 2012

Claudia Ulbrich as Chief Executive Officer. Pharmacological inhibition mediated by antisense oligonucleotides of these microRNAs, leds to partial blockage in development of cardiac hypertrophy, paving a way for future therapeutical application. Insufficient myocardial capillary density after MI has been identified as a critical event in the remodelling process that can be targeted with novel therapeutic strategies. Cardior is the winner of the Startup Challenge at Deutsche Biotechnologietage , the largest German biotech summit. Diabetes is a pro-coagulatory state characterized by enhanced platelet activation, aggregation and adhesion that shifts the normal hemostatic balance towards thrombosis and increases the risk of coronary artery disease. The mitochondrial lncRNA ucbqs. February The human genome is like a giant library harboring billions of books, the collective information of life.

Thum was asked and joined the Editorial Board of the journal Circulation Research. The junior scientist Dr. After global miRNA profiling, a set of miRNAs was identified that was differentially regulated in patients with MS when compared with that of affected individuals by other neurological diseases. IMTTS identifies a novel therapy for reducing doxorubicin-induced cardiotoxicity. Thomas Thum and Dr. Despite the preliminary character of the promising initial data, the results provide rationale for a confirmation study in larger MS cohorts.

Publication highlights the protective role of Quaking in preventing doxorubicin-induced cardiotoxicity. March IMTTS Researchers together with French colleagues identified a novel Biomarker of cardiac remodeling and for prediction of cardiovascular mortality in heart failure patients.

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Dissertatio meeting Experimental Biology EB is held annually involving five societies and bringing together more than 12, scientists and 25 guest societies in one interdisciplinary community. The findings are published in the journal Circulation Research. April Physiological aging and senescence are associated to progressive decline in most physiological functions, reduced response to stress, loss of viability and increased susceptibility to various diseases.

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He and mh team will use the new funding of 1.

mhh dissertation 2012

With this method hundreds of different miRNAs can be overexpressed or silenced in basically any target cell with subsequent testing of functional consequences. Thum was asked and joined the Editorial Board of the journal Circulation Research. COST actions do not support individual research projects but dissertagion networking activities, like congresses and exchange of scientists.

mhh dissertation 2012

New miRNA-based therapeutic strategy of acute kidney injury developed. HiLF II is intended as initial funding for starting a new line of research also with the aim to apply for subsequent third party myh.

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The 2 years program will include different modules aiming to understand the finding, development and application of drug candidates. We show that miR acts as a critical regulator of endothelial cell apoptosis and angiogenesis and is suitable for therapeutic intervention in the setting of ischemic heart disease.

Diabetes is a pro-coagulatory state characterized by enhanced platelet activation, aggregation and adhesion that shifts the normal hemostatic balance towards thrombosis and increases the risk of coronary artery disease. In contrast, cardiotropic AAV9-mediated overexpression of OPN adenoviral constructs in vivo further enhanced cardiac fibrosis.

Mechanistically, miR silenced phosphatase and tensin homolog PTEN in endothelial cells resulting in activation of the Akt-pathway. We previously showed blocking certain small Mh molecules, so called microRNAs, in the heart to prevent the development of heart failure.

November Professor Thomas Thum and Dr. The details about this work can be found here: July The Physiological Society invited Dr. With more than active participants the meeting was the so far largest meeting of the Working Groups and a great success. The researchers have published their findings in Nature Communications 25 September In the other part of his work, he also focussed on evaluation of circulating microRNAs as diagnostic and prognostic biomarker for patients with acute myocardial infarction.

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The core of drug development is the founding of the spin-off biotech company Cardior Pharmaceuticals GmbH which functions to translate the RNA structures, which were identified in MHH for the treatment of cardiovascular diseases, into drugs and applications in humans.

The current list of Highly Cited Researchers https: Cardior is pioneering its proprietary RNA technology to revolutionize predicting and treating dizsertation failure.

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Sandor Batkai was awarded a three year Marie Curie Grant by the European Commission to support his professional reintegration to Germany. Small interference RNA-mediated silencing of mimecan in cardiac fibroblasts mimicked the miRmediated effects. As transforming growth factor TGF -beta is linked to abnormal vessel function and can mediate impairment of endothelial angiogenic responses we studied its effects on microRNAs expression and identified miRa-3p, along with other members of the miR family, to be strongly silenced.

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Selected miRNAs are strongly altered in urine of the patients with acute renal allograft rejection. Researchers at Disertation will specifically investigate the diagnostic and prognostic power of circulating microRNAs in elderly heart failure patients within the next 6 years. Seema Dangwal will receive training on laser capture microscopy at Harvard core facility and initiate dissertahion collaboration with Prof.

Therefore, miR inhibition may be a promising future therapeutic option in the treatment of patients with ischemic AKI. IMTTS researchers at